Neurodegenerative Diseases and Stem Cell Transplantation
نویسنده
چکیده
Abbreviations: AD: Alzheimer’s Disease; ASCs: Adult Stem Cells; BDNF: Brain Derived Neurotrophic Factor; CNS: Central Nervous System; ESCs: Embryonic Stem Cells; FGF-2: Fibroblast Growth Factor 2: HD: Huntington’s Disease; HSCs: Haematopoietic Stem Cells; IBMX: 3-Isobutyl-1-methylxanthine; L-DOPA: L-dihydroxyphenyl alanine; MPTP: 1-methyl-4phenyl-1, 2,3,6 tetrahydropyridine; MS: Multiple Sclerosis; MSCs: Mesenchymal Stem Cells; PD: Parkinson’s Disease
منابع مشابه
O19: Advances in the Treatment and Limitations of Cell Therapy in Neurodegenerative Diseases
Neurodegenerative diseases are the hereditary and sporadic diseases which are characterized by progressive neuronal loss of the nervous system and are emerging as the leading cause of death, disabilities, and a socioeconomic burden due to an increase in life expectancy. There are many neurodegenerative diseases including Alzheimer’s disease, Parkinson’s, disease, amyotrophic lateral...
متن کاملEffect of the Xenograft Transplantation of Human Dental Pulp Stem Cells on Anxiety and Memory in Trimethyltin Induced-Alzheimer Disease Model
Background and Objectives: Alzheimer's disease (AD) is a neurodegenerative disease and the most common cause of dementia. The characteristics of this disease are amnesia, cognitive and verbal disorders, memory deficit, paranoia, depression, and anxiety. In this study, the alterations of cognitive-behavioral and nuclear factor kappa (NF-κ) factor, were investigated following the xenogenic transp...
متن کاملکاربرد سلول های بنیادی در درمان بیماری پارکینسون
Stem cells are undifferentiated cells with the ability to divide and differentiate into distinct cell types. The source of these cells is from embryos and adults, that each cell has its own specific characteristics. For nearly decades, experimental studies have been conducted to use these types of cells to treat various diseases. Parkinson's disease is one of the most common neurodegenerative d...
متن کاملExpression of Neurotrophins in Adipose-derived Stem Cells during in vitro Culture and Posttransplantation in Parkinsonian Rat Model
Background: Adipose tissue stem cells (ASCs) cause faster repair of damaged tissue posttransplantation by releasing growth factors in neurodegenerative diseases. ASCs secrete factors in the culture medium called conditioned medium (CM) in vitro. This study investigated the expression of neurotrophin genes in vitro culture and transplant of ASCs in Parkinsonian rats. Materials and Methods: In th...
متن کاملRecent Technological Advances in Hepatogenic Differentiation of Stem Cells Relevant to Treatment of Liver Diseases
Liver failure, in an acute or chronic form, is a growing health problem ranking as one of the leading causes of death worldwide. Inborn errors of metabolism characterized by defects in hepatic enzymes or other proteins with metabolic functions, such as receptors or transporters accompanied with environmental factors involve etiology and presentation of liver failure. Currently, the only establi...
متن کاملP91: Auto Graft Transplantation of Adult Human Neural Stem Cells in Treatment of Traumatic Brain Injury as a Hypothesis
Traumatic brain injury (TBI) leading to 5 million deaths annually is 1 of the 5 major causes of morbidity and mortality worldwide. In Iran, accidents are the main cause of death in youth as well as a dominant factor in reducing quality of life. In developing countries TBI incidence as one of the worst consequences of these accidents is growing due to wide use of motor-vehicles. Therapeutic stra...
متن کامل